Epitranscriptomic chemical RNA modifications have recently emerged as a new layer of post-transcriptional gene regulation. Recent advancements in methylated RNA immunoprecipitation sequencing (m6A-seq) and mass spectrometry have revealed widespread chemical modifications on diverse RNAs, including mRNA, tRNA, rRNA, microRNA, and long-noncoding RNA. Currently, > 170 RNA modifications have been identified in living organisms. Among them, N6-methyladenosine (m6A) is the most prevalent modification found in eukaryotic mRNAs. In recent years, cellular factors adding, deleting, and interpreting m6A marks, designated as “writers” (methyltransferases), “erasers” (demethylases), and “readers” (m6A-binding proteins), respectively, have been identified in plants and animals. An emerging body of evidence shows that methylation on mRNAs affects diverse aspects of RNA metabolism, including stability, splicing, nucleus-to-cytoplasm export, alternative polyadenylation, and translation. In particular, the roles of writers, readers, and erasers in plants are rapidly uncovered, which clearly demonstrates that they are essential for plant growth and abiotic stress responses. In this talk, I will introduce several key findings via analyzing the mutants of m6A writers, erasers, and readers, which emphasizes the crucial roles of epitranscriptomic chemical mRNA methylation in the plant growth, development, and stress responses.